Objective To explore the effectiveness of Platelet-Rich Plasma (PRP) combined with Wen Shen Formula in treating thin endometrium.

Methods From January 2019 to January 2023, 90 patients with thin endometrium-related infertility who showed poor response to standard Hormone Replacement Therapy (HRT) in our Reproductive Endocrinology Department were studied. Patients receiving PRP infusion + Wen Shen Formula enema (Group A, n = 45) were compared with those receiving only PRP infusion (Control Group B, n = 45) in terms of endometrial thickness, embryo implantation rate, clinical and ongoing pregnancy rates.

Results Compared to the control group, Group A showed a significant increase in endometrial thickness after 13 days, with statistically significant differences between the groups (P < 0.05). There were also significant differences in biochemical pregnancy, miscarriage, and ongoing pregnancy rates (P < 0.05).

Conclusion Platelet-rich plasma (PRP) combined with Wen Shen Formula enema effectively promotes the growth of thin endometrium in patients and improves pregnancy outcomes. It can be considered a safe and effective method for clinical treatment of patients with thin endometrium-related infertility.