Exploring Oncogenic Factors Influence on Multiple Myeloma Progression and Patient Survival

Backgrounds Multiple myeloma (MM), one of the most prevalent hematological malignancies, is characterized by the proliferation of plasma cells within bone marrow and concurrent development of osteolytic lesions. The persistence of myeloma cells in the hypoxic bone marrow environment, coupled with their resistance to current therapeutic approaches, often results in relapse. Hence, there is an immediate imperative to decipher the molecular mechanisms underpinning myelomagenesis to pave the way for more efficacious treatment modalities. While prior investigations have predominantly focused on delineating the roles of individual genes in myelomagenesis, this article offers a comprehensive analysis of the current research landscape encompassing four distinct oncogenic gene signatures and their impact on patients' survival outcomes.

Methods We utilized the most robust RNAseq datasets, GSE13591 and Compass AI8 to evaluate hypoxia, MM bone disease (MBD), dormancy and para-inflammation genes signatures. Fisher’s least significant difference post hoc tests were used to determine significance between MM groups while Spearman R-value was calculated to assess regression and correlation among each gene signature. Each signature was grouped as Low and high expression based on median and survival outcomes was plotted using the Kaplan Meier.

Results While prior investigations have predominantly focused on delineating the roles of individual genes in myelomagenesis, this article offers a comprehensive analysis of the current research landscape encompassing four distinct oncogenic gene signatures and their impact on patients' survival outcomes. Through the collective analysis of these gene signatures, we gain invaluable insights into the intricate molecular cues that initiate and propel MM progression. Furthermore, this article sheds light on the intricate interplay among these oncogenic gene signatures, illustrating how they intersect and synergistically influence MM's pathogenesis.

Conclusion In conclusion, this article underscores the paramount importance of a comprehensive examination of the four oncogenic gene signatures associated with myelomagenesis. By considering their collective impact on patient survival and elucidating their intricate interrelationships, we significantly augment our understanding of the complex molecular landscape governing MM.